a Record control number WOS:000253393200008

a ISSN 0002-9629

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WB115

b Item number .E96 2008

a Personal name Buyukasik, Yahya.

h Medium Electronic Document

a Title Evidence for higher red blood cell mass in persons with unconjugated Hyperbilirubinemia and Gilbert's syndrome

c Statement of responsibility, etc Yahya Buyukasik, Umit Akman, Naciye S. Buyukasik, Hakan Goker, Alparslan Kilicarslan, Ali Shorbagi, Gulsen Hascelik, Ibrahim C. Haznedaroglu.

b Name of publisher, distributor, etc Lippincott Williams & Wilkins,

c Date of publication, distribution, etc 2008.

a Summary, etc Background: The genetic polymorphism responsible from Gilbert's syndrome is not sufficient for the clinical phenotype to occur in many persons. Additional factors are believed to contribute in pathogenesis. Red cell mass may be such a factor. Methods: We have retrospectively evaluated computer records of all liver function tests assayed between January 2005 and February 2006. The database was screened to find cases with unconjugated hyperbilirubinemia and normal liver enzymes and blood count values on simultaneous assays. The control group for comparison of surrogate markers of total red cell mass comprised of age- and gender-matched persons who had laboratory tests with completely normal results on the same day with the hyperbilirubinemic cases. Gilbert's syndrome cases were found with medical record assessment, and these cases and their control subjects were more strictly assessed. Three different control groups were established for Gilbert's syndrome cases, one of them including healthy blood donors and personnel. Results: In 48,516 otherwise normal laboratory test results, we have found that 491 male subjects and 323 female subjects with unconjugated hyperbilirubinemia had higher hemoglobin, hematocrit, and red blood cell values compared with age-and gender-matched control subjects (P < 0.001 for all comparisons). Twenty-six males who had been followed for Gilbert's syndrome also showed higher hemoglobin, hematocrit and red cell count values in comparison to all control groups. Mean red cell volume value did not differ between the hyperbilirubinemic persons and control groups. Conclusions: Relatively increased red cell mass probably plays a role in the pathogenesis of Gilbert's syndrome.

a Topical term or geographic name as entry element Internal Medicine

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information FEB 2008, Vol.335 Issue 2, p115-119

t Title American journal of the medical sciences

x International Standard Serial Number 00029629